The thyroid
gland is a butterfly shaped organ in the front part of the lower
neck. The thyroid has two lobes, connected by a center
section called the isthmus (see below):
One of the main functions of the thyroid is
the control of the metabolism rate - the rate at which cells
burn fuel to produce energy. Thus, metabolism controls
body temperature and weight. The thyroid uses an amino
acid called tyrosine to make two of the hormones it uses to
control metabolism. The thyroid combines tyrosine with
iodine to make thyroxine (T
4) and triiodothyronine (T
3).
In order for the thyroid to function properly and make T
3
and T
4, the body must have an adequate dietary intake
of iodine. A condition called
goiter
results when there is no enough iodine or too much iodine.
The thyroid hormones thyroxine (T
4)
and triiodothyronine (T
3) are used by every cell in
the body to control metabolism. A healthy thyroid makes
80% T
4 and 20% T
3. Even though there
is less T
3 made, it has about the same potency since
its hormonal strength is about four times that of T
4.
As mentioned previously, the amount of T
3 and T
4
made is controlled via TSH from the
pituitary gland using a
feedback loop as shown below. Hyperthyroidism occurs when
there is too much T
3 and T
4 produced, and
hypothyroidism occurs when there is not enough T
3 and
T
4 produced.
Parts of the Thyroid
Besides T
3 and T
4, the
thyroid also controls calcitonin, which regulates the amount of
calcium in the blood which is stored in the bones. The
parathyroid controls the
amount of calcium removed from the bones.